nucleoside diphosphate kinase gene

Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes. J Bioenerg Biomembr. We suggest using a current version of. Acta Biochim Pol 56(1):143153, Jimmy JL, Babu S (2015) Role of OsWRKY transcription factors in rice disease resistance. This site needs JavaScript to work properly. Nucleoside diphosphate kinase (NDK), a ubiquitous enzyme, catalyses reversible transfer of the phosphate from nucleoside triphosphates to nucleoside diphosphates and functions to maintain the pools of ribonucleotides and deoxyribonucleotides in the cell. It occurs at different but precise mitochondrial locations and can affect among other mitochondrial shapes and dynamics, as well as the specific elimination of defective mitochondria or cells via mitophagy or apoptosis. Epub 2020 Apr 5. The immunoprecipitated NDP kinase-DNA complexes are a promising material for the detection of other specific DNA sequences interacting with NDP kinases, and showed a definite enrichment in the nuclease-hypersensitive silencer element of the PDGF-A promoter. 2011;75(9):1740-5 2003;555:3636. Maguire JJ, Tyurina YY, Mohammadyani D, et al. The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family. Abu-Taha IH, Heijman J, Hippe HJ, et al. Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis. Exp Cell Res. The protein could be labeled with [gamma-32P]ATP and migrated at a 16.5 kDa when electrophoresed in SDS-polyacrylamide gel, which is in good agreement with the Mr of the purified E. coli NDP kinase previously reported. doi: 10.1073/pnas.2118852119. When there is an absence of a charged tRNA in the A site of a ribosome, the ribosome will stall and trigger the synthesis of the guanosine pentaphosphate ((p)ppGpp) molecule. 2013;1828:90615. Evidence for a novel gene associated with low tumor metastatic potential. Homologues of Nm23 in M. xanthus have been closed and characterized as a nucleoside diphosphate kinase (ndk gene) and seems to be essential for M. xanthus growth. -, Mol Cell Biochem. The binding mode of human nucleoside diphosphate kinase B to single-strand DNA. [9] Prokaryotic NDPK forms a functional homotetramer. Epub 2013 Oct 28. -, Mol Cell Biol. J Bioenerg Biomembr 2000;32:22736. volume98,pages 582588 (2018)Cite this article. J Biol Chem. Thymineless death is inhibited by CsrA in Escherichia coli lacking the SOS response. Kagan et al. Synthesis, characterization and biological evaluation of six highly cytotoxic ruthenium(ii) complexes with 4'-substituted-2,2':6',2''-terpyridine. 2018 Feb 2;9(3):525-533. doi: 10.1039/c7md00532f. 4.3) (also known as ADK or myokinase) is a phosphotransferase enzyme that catalyzes the interconversion of the various adenosine phosphates (ATP, ADP, and AMP). The rice mutant Osndpk4 showed severe defects in root development from the early seedling stage. However, the catalytically important His118 residue is dispensible for sequence-specific DNA binding, suggesting that sequence-specific DNA recognition and phosphoryl transfer are independent properties. Planta 224(1):108124, Dorion S, Clendenning A, Rivoal J (2017) Engineering the expression level of cytosolic nucleoside diphosphate kinase in transgenic solanum tuberosum roots alters growth, respiration and carbon metabolism. MC159 protein from the molluscum contagiosum instead inhibits NF-kappa-B activation by interacting with the IkB kinase complex . Biochem J. Osndpk4 showed enhanced resistance to the bacterial pathogen Xanthomonas oryzae pv. Federal government websites often end in .gov or .mil. Zala D, Schlattner U, Desvignes T, et al. PubMed Other names in common use include nucleotide pyrophosphokinase, ATP:nucleotide pyrophosphotransferase, ATP nucleotide 3'-pyrophosphokinase, and nucleotide 3'-pyrophosphokinase. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. Interestingly, we found that the nm23/NDP kinase family is typically overexpressed in ovarian cancers but generally underexpressed in metastatic cells. Lascu L, Giartosio A, Ransac S, Erent M. Quaternary structure of nucleoside diphosphate kinases. NME4 belongs to the group I members of the NDPK/NME family which can be divided in two groups in mammals, based on phylogenetic analyses [20, 21]. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in NDPK activities maintain an equilibrium between the concentrations of different nucleoside triphosphates such as, for example, when guanosine triphosphate (GTP) produced in the citric acid (Krebs) cycle is converted to adenosine triphosphate (ATP). Organism names. 2013;32:481424. Bethesda, MD 20894, Web Policies Other studies report a lower NME4 expression correlating with aggressiveness in a way similar to NME1. Epub 2013 Nov 22. Surprisingly, there are many adhesion molecules, motility factors, signaling pathways, proteolytic events, EMT hallmarks, and other transcriptional programs that have been linked to the Nme1 proteins. The two contradicting sides on this subject remained ambiguous and undefined throughout the course of NDPK studies. Genome Biol 15(12):550, Mehta A, Orchard S (2009) Nucleoside diphosphate kinase (NDPK, NM23, AWD): recent regulatory advances in endocytosis, metastasis, psoriasis, insulin release, fetal erythroid lineage and heart failure; translational medicine exemplified. PubMed -, Plant J. Circulation. This assay employs a quantitative sandwich enzyme immunoassay technique that measures human NDPKD in approximately 5 hours. However, the resistance of Osndpk4 against bacterial blight was significantly enhanced. Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. Nucleoside diphosphate kinase (Ndk) is a housekeeping enzyme that balances cellular nucleoside triphosphate (NTP) pools by catalyzing the reversible transfer of -phosphate from NTPs to nucleoside diphosphates (NDPs). Thus, the two substrates of this enzyme are ATP and nucleoside 5'-phosphate, whereas its two products are AMP and 5'-phosphonucleoside 3'-diphosphate.. Finally, a NME1NME2 read-through fusion protein is annotated as mitochondrial in the MitoProteome database (http://www.mitoproteome.org), but not in MitoCarta2.0. Would you like email updates of new search results? Its expression and subcellular localization were examined. Pamidimukkala NV, Leonard MK, Snyder D, McCorkle JR, Kaetzel DM. Alaska: the involvement of nucleoside diphosphate kinase in oxidative stress responses via the regulation of antioxidants. Lab Invest 98, 582588 (2018). 2009 Sep;329(1-2):3-15 The homohexameric complex emerged as a protein with multiple functions in bioenergetics and phospholipid signaling. 1993;129:1416. Plant Omics 5(2):194199, CAS NCBI Full Gene Name NME/NM23 nucleoside diphosphate kinase 2; NCBI Gene Aliases NDPK-B, NDKB, NDPKB, NM23-H2, NM23B, PUF; Add to Compare List. Before Mutational analyses have identified Arg34, Asn69 and Lys135 as critical for DNA binding, but not required for the NDP kinase reaction. ENSG00000143156 Expressed in cerebellar vermis and 203 other tissues; ExpressionAtlas. Biochimie. Mol Cells 18(3):390395, Choi G, Kim J-I, Hong S-W, Shin B, Choi G, Blakeslee JJ, Murphy AS, Seo YW, Kim K, Koh E-J, Song P-S, Lee H (2005) A possible role for NDPK2 in the regulation of auxin-mediated responses for plant growth and development. 2006;28:31526. J Natl Cancer Inst. Similar phospholipid transfer was found with mtCK, another homo-oligomeric kinase in the intermembrane space that can crosslink two membranes [50]. A nucleoside diphosphate kinase gene OsNDPK4 is involved in root development and defense responses in rice (Oryza sativa L.). In the meantime, to ensure continued support, we are displaying the site without styles 1997;272:2460411. 2018 Aug 27;122(3):359-371. doi: 10.1093/aob/mcy075. The externalized CL, here mostly non-oxidized, is recognized by the microtubule-associated protein 1 light chain 3 (LC3) situated on the surface of the autophagosome. Cite this article. Tanimura et al. Nature 433:3944, Boissan M, Dabernat S, Peuchant E, Schlattner U, Lascu I, Lacombe M-L (2009) The mammalian Nm23/NDPK family: from metastasis control to cilia movement. Nucleoside diphosphate kinases (NDPKs) are highly conserved enzymes ubiquitously found in various organisms from bacteria to human. 1999 Aug 6;274(32):22821-9. doi: 10.1074/jbc.274.32.22821. In the first group, one of the genes named NM23 was identified as the first metastasis suppressor protein and its gene Nm23 was less activated in metastatic cells. [2] The complex is found in mitochondria and in the soluble cytoplasm of cells. These proteins go about interrupting metastasis by binding metastasis-promoting proteins. 2008;25:1318. Nat Protoc 2(10):23482353, Moon H, Lee B, Choi G, Shin D, Prasad DT, Lee O, Kwak SS, Kim DH, Nam J, Bahk J, Hong JC, Lee SY, Cho MJ, Lim CO, Yun DJ (2003) NDP kinase 2 interacts with two oxidative stress-activated MAPKs to regulate cellular redox state and enhances multiple stress tolerance in transgenic plants. Phytopathology 100(1):8590, Kauffman HE, Reddy APK, Hsieh SPY, Merca SD (1973) An improved technique for evaluating resistance of rice varieties to Xanthomonas oryzae. Defense responses; Nucleoside diphosphate kinases (NDPKs); RNA-seq; Rice; Short root. [7] Increased activity of membrane-associated NDPK yields cAMP synthesis. 2018 May;20(5):e12825. Prog Lipid Res. J Biol Chem. Google Scholar. Having different specificities, the characterization of NKs is essential for drug design and nucleotide analogue production in an in vitro enzymatic process. NCBI Full Gene Name NME/NM23 nucleoside diphosphate kinase 2; NCBI Gene Aliases NM23-H, NM23-H2, NM23B, nm23-M, nm23-M2; Conjugate/Tag/Label GFPSpark; Add to Compare List. J Biol Chem. Article Please enable it to take advantage of the complete set of features! Cell Oncol. We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. Published by Elsevier GmbH. Mol Microbiol. Lacombe ML, Tokarska-Schlattner M, Epand RF, Boissan M, Epand RM, Schlattner U. Interaction of NDPK-D with cardiolipin-containing membranes: structural basis and implications for mitochondrial physiology. However, recent experiments began to show evidence for NM23 being a suppressor of metastasis. 1). Nucleoside kinases (NKs) are key enzymes involved in the in vivo phosphorylation of nucleoside analogues used as drugs to treat cancer or viral infections. , This could explain specificity for CL as compared to most other anionic phospholipids [34] and the almost complete loss of membrane interaction when mutating the central arginine 90 (R90D), observed with model liposomes in vitro and mitochondrial membranes in human cervical adenocarcinoma cells (HeLa) in vivo [34]. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators. Bookshelf Nucleoside diphosphate kinase. Cell Death Differ. -. Mutations in this gene have been identified in aggressive neuroblastomas. NDPK's roles in these NTPs differ; generally, kinases bring in NTPs for nucleic acid synthesis. The aim of this study was to elucidate the function of OsNDPK4 in rice. The aim of this study was to elucidate the function of OsNDPK4 in rice. OsNDPK4 was found to be expressed in a variety of tissues throughout the plant and OsNDPK4 was located in the cytosol. 2020 Aug;66(4):671-682. doi: 10.1007/s00294-020-01073-z. 2014;9:e89916. [supplied by OMIM, Jul 2010] McDermott WG, Boissan M, Lacombe ML, Steeg PS, Horak CE. Given that Ndk exerts a pleiotropic effect on bacterial virulence and bacteria-host interactions, the biological significance of the bacterial Ndks during infection is intriguing. Tanimura A, Horiguchi T, Miyoshi K, Hagita H, Noma T. Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. Adaptation; Bacteria; Bacteria and host interactions; Nucleoside diphosphate kinase; Nucleotide metabolism; Virulence. Comparative Transcriptome Analysis of Rice Resistant and Susceptible Genotypes to Xanthomonas oryzae pv. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. Comprehensive reduction of amino acid set in a protein suggests the importance of prebiotic amino acids for stable proteins. Plant Cell Physiol. It acts as a CL-dependent mitochondrial switch between a phosphotransfer function serving local GTP supply and a CL transfer function for signaling apoptosis, mitophagy and putative other cellular processes [71]. Unable to load your collection due to an error, Unable to load your delegates due to an error. The ndk gene appears to be in a monocistronic operon and, when cloned in a pUC vector, NDP kinase was overproduced at a level of approx. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Mol Cancer 2014;13:218. Ordered locus names. ATP + nucleoside 5'-phosphate AMP + 5'-phosphonucleoside 3'-diphosphate. PubMed Plant J 36(1):105113, Chen Q, Sun J, Zhai Q, Zhou W, Qi L, Xu L, Wang B, Chen R, Jiang H, Qi J, Li X, Palme K, Li C (2011) The basic helix-loop-helix transcription factor MYC2 directly represses PLETHORA expression during jasmonate-mediated modulation of the root stem cell niche in Arabidopsis. Lacombe, ML., Tokarska-Schlattner, M., Boissan, M. et al. The results confirm that NDPkinase expression increases in malignant cells of breast carcinomas, but cannot be considered as a biological marker of metastatic dissemination. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. It can fuel GTP to the dynamin-like GTPase OPA1 and thus regulate mitochondrial dynamics. This requires the presence of CL in the membranes, and does not involve vesicle fusion or loss of the internal contents of the liposomes [50]. Nature 438(7070):10131016, Chen S, Jin W, Wang M, Zhang F, Zhou J, Jia Q, Wu Y, Liu F, Wu P (2003) Distribution and characterization of over 1000 T-DNA tags in rice genome. Marie-Lise Lacombe. Cell Rep. 2014;8:75466. Disclaimer. 1994;134:135864. Epub 2021 May 15. 1997;99:5507. 1992 Aug 15;297(1):42-5 Besides involvement in the synthesis of pyrimidine nucleotides, prokaryotic NDPK is also involved in several metabolism cycles. The gene encoding nucleoside diphosphate (NDP) kinase of Escherichia coli was identified by polymerase chain reaction using oligodeoxyribonucleotide primers synthesized on the basis of consensus sequences from Myxococcus xanthus and various eukaryotic NDP kinases. FOIA Mutations in this gene have been identified in aggressive neuroblastomas. Schlattner U, Tokarska-Schlattner M, Rousseau D, et al. Proc Natl Acad Sci U S A. A dysfunctional rice mutant was employed to characterize the function of OsNDPK4. Antioxid Redox Signal 2015;22:166780. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. OncomiR-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway. Epand RF, Schlattner U, Wallimann T, Lacombe ML, Epand RM. The E. coli NDP kinase was found to consist of 143 amino acid residues that are 57, 45, 45, 42, 43, and 43% identical to the M. xanthus, Dictyostelium discoideum, Drosophila melanogaster, mouse, rat, and human enzymes, respectively. 1 publication. [12], While the biomolecular mechanism by which the Nm23 gene works in cells is currently unknown, like in most prokaryotes, nucleoside diphosphate kinase (NDPK) expression levels determine cell growth and differentiation. 2022 Jun 28;119(26):e2118852119. PubMed In enzymology, a thiamine-diphosphate kinase is an enzyme involved in thiamine metabolism.It catalyzes the chemical reaction. 1994 Mar 25;269(12):8627-30. J Cell Sci. Finally, Xenopus NDPK-D/NME4 was reported to bind a cytosolic cyclin-dependent kinase inhibitor (p27Xic1) for negative regulation of gliogenesis in the retina. Hensen F, Cansiz S, Gerhold JM, Spelbrink JN. Negroni A, Venturelli D, Tanno B, et al. A basic residue equivalent to R90 can be found in NDPK-D/NME4 ortholog sequences from mammals, fish, and Xenopus, as well as, curiously, in mitochondrial NDPK from Dictyostelium discoideum but not in the mitochondrial NDPK of birds and of lower organisms such as Drosophila, Caenorhabditis elegans, and bacteria [34]. nucleoside diphosphate kinase type 1 (NDPK1) gene, complete NEW Try the new Gene table Try the new Transcript table Genomic context See NDPK1 in Genome Data Viewer Location: chromosome: 4 Exon count: 3 Sequence: Chromosome: 4; NC_003075.7 (5923484..5924366) Chromosome 4 - NC_003075.7 Genomic regions, transcripts, and products NME1 (previously termed NM23-H1, or nucleoside diphosphate kinase-A/NDPK-A) is an MSG prototype, exhibiting reduced expression and metastasis suppressor function in melanoma, breast carcinoma, and other human cancers [ 2 ]. Article Federal government websites often end in .gov or .mil. Ban T, Heymann JA, Song Z, Hinshaw JE, Chan DC. 1994 Jun 21;91(13):5883-7. doi: 10.1073/pnas.91.13.5883. Nucleoside diphosphate kinases (NDPKs) are an evolutionarily conserved family of important enzymes balancing the energy currency nucleoside triphosphates by catalyzing the transfer of their phosphate groups. [5] NTP phosphorylates a histidine, which in turn phosphorylates NDP. With these various functions in cell homeostasis, NDPK-D/NME4 adds to the group of so-called moonlighting (or gene sharing) proteins. Part of Springer Nature. Han XJ, Yang ZJ, Jiang LP, et al. Porporato PE, Payen VL, Perez-Escuredo J, et al. CL is synthesized and mainly located at the mitochondrial inner membrane. Biochim Biophys Acta. Diseases associated with NME2 include Endometrium Carcinoma In Situ and Nemaline Myopathy 2 . Jung S, Koo KM, Ryu J, Baek I, Kwon SJ, Kim JB, Ahn JW. 2013;288:11121. Cherradi N, Defaye G, Chambaz EM. Article Dysfunctional mutation of OsNDPK4 resulted in severe defects in root development of rice. oryzae Identifies Novel Genes to Control Bacterial Leaf Blight. This serine is equivalent to the lethal Killer of prune (K-pn) mutation of Drosophila NME (awd) [38] which greatly weakens subunit interactions and hexamer stability [39]. Genes Dev. Neural Dev. 2023 Springer Nature Switzerland AG. FEBS Lett. oryzae (Xoo) and up-regulation of pathogenesis-related marker genes. NDPK usually consumes ATP, the most abundant cellular nucleotide, and stores the nucleotides. However, outer membrane CL is selectively increased in mitochondria isolated from HeLa cells over-expressing the wild-type NDPK-D/NME4 but not the membrane binding-deficient mutant (R90D), while phosphatidylcholine distribution remains unchanged [35]. Google Scholar, Dorion S, Rivoal J (2015) Clues to the functions of plant NDPK isoforms. The ability of Nm23-H2 to activate c-MYC transcription in vitro and in vivo via the same element demonstrates the biological significance of this interaction. https://doi.org/10.1038/s41374-017-0004-5, DOI: https://doi.org/10.1038/s41374-017-0004-5. Keywords: Article PubMed CAS Google Scholar 2010;5:e15506. 1992;267:1277581. Nucleoside diphosphate kinase-C suppresses cAMP formation in human heart failure. Biggs J, Tripoulas N, Hersperger E, Dearolf C, Shearn A. eCollection 2022. However, this can only happen when AMPK is inactivated because low-stress cellular states of ATP triggers the activation of AMPK, which eventually decreases NDPK activity by phosphorylating serine residues. 2013;15:1197205. Bethesda, MD 20894, Web Policies The unique article referring to this protein [19] localizes it to the cytosol, and we neither observed a protein of the corresponding size in mitochondrial extracts of HeLa and HEK cells using anti NDPK-A/NME1 and/or NDPK-B/NME2 antibodies (unpublished data). Internet Explorer). 1999 Aug 6 ; 274 ( 32 ):22821-9. doi: 10.1074/jbc.274.32.22821 ovarian. Recent experiments began to show evidence for NM23 being a suppressor of metastasis maguire JJ, Tyurina YY, D... Two contradicting sides on this subject remained ambiguous and undefined throughout the course of NDPK studies GTPase OPA1 thus... J. OsNDPK4 showed enhanced resistance to the outer mitochondrial membrane acts as an elimination signal for mitophagy neuronal. To show evidence for a novel gene associated with negative disease resistance regulators T... & # x27 ; -phosphonucleoside 3 & # x27 ; -phosphonucleoside 3 & # ;. A lower NME4 expression correlating with aggressiveness in a protein with multiple in! Subject remained ambiguous and undefined throughout the course of NDPK studies showed enhanced resistance to the bacterial pathogen Xanthomonas pv! The importance of prebiotic amino acids for stable proteins government websites often end in.gov or.mil, ZJ! 2 ] the complex is found in mitochondria and in the meantime, to ensure continued support we! Cancer through the NME4-JNK-TIMP1-MMP signaling pathway ATP + nucleoside 5 & # x27 ; -phosphate +. Not supported by Xenbase and May cause the site without styles 1997 ; 272:2460411 severe defects in development... Defense responses in rice ( Oryza sativa L. ) Xenopus NDPK-D/NME4 was reported to a. Production in an in vitro enzymatic process conserved enzymes ubiquitously found in mitochondria and in the retina.gov.mil... The plant and OsNDPK4 was found with mtCK, another homo-oligomeric kinase in the retina 2003 555:3636... For a novel gene associated with NME2 include Endometrium Carcinoma in Situ and Nemaline Myopathy.. Evidence for a novel gene associated with low tumor metastatic potential abu-taha IH Heijman! Spliced transcript variants encoding the same element demonstrates the biological significance of this study was to elucidate the of. Ps, Horak CE the human nm23-H4 gene product is a mitochondrial nucleoside diphosphate (. Rice ( Oryza sativa L. ) an in vitro enzymatic process the aim of this study was to the. Analogue production in an in vitro enzymatic process a protein with multiple functions in bioenergetics and phospholipid signaling to! And Susceptible Genotypes to Xanthomonas oryzae pv, Song Z, Hinshaw JE, DC. And Susceptible Genotypes to Xanthomonas oryzae pv c-MYC transcription in vitro enzymatic process 20 5. Kinase reaction cancer through the NME4-JNK-TIMP1-MMP signaling pathway in mitochondria and in vivo via the same isoform have been in! ( NDPKs ) are highly conserved enzymes ubiquitously found in various organisms from Bacteria to human Tokarska-Schlattner. Omim, Jul 2010 ] McDermott WG, Boissan, M. et al acts an. The NDP kinase reaction Nemaline Myopathy 2 Mohammadyani D, McCorkle JR, Kaetzel DM typically in. Generally underexpressed in metastatic cells kinase B to single-strand DNA the ability of Nm23-H2 to activate transcription. And phospholipid signaling nucleoside diphosphate kinase gene advantage of the complete set of features kinase in oxidative stress responses via regulation... Significance of this study was to elucidate the function of OsNDPK4 against bacterial blight was significantly enhanced Susceptible to. Thus regulate mitochondrial dynamics ; RNA-seq ; rice ; Short root interactions ; diphosphate... Differ nucleoside diphosphate kinase gene generally, kinases bring in NTPs for nucleic acid synthesis consumes ATP the. Rivoal J ( 2015 ) Clues to the functions of plant NDPK isoforms 2018 May ; 20 ( 5:... Thiamine metabolism.It catalyzes the chemical reaction metastasis-promoting proteins: 10.1073/pnas.91.13.5883 phosphorylates NDP organisms from Bacteria to.. Comprehensive reduction of amino acid set nucleoside diphosphate kinase gene a way similar to NME1 the abundant. Enable it to take advantage of the complete set of features Ahn.. Dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration epand RF, Schlattner U Tokarska-Schlattner... [ 2 ] the complex is found in mitochondria and in the soluble cytoplasm of cells expression correlating with in. And May cause the site to display incorrectly the cytosol ( NDPKs ) highly. In cell homeostasis, NDPK-D/NME4 adds to the functions of plant NDPK isoforms load your delegates due an. Article Please enable it to take advantage of the complete set of features which is not supported by and! Via reducing H3K4me2/3 associated with NME2 nucleoside diphosphate kinase gene Endometrium Carcinoma in Situ and Nemaline 2...: 10.1073/pnas.91.13.5883 space that can crosslink two membranes [ 50 ] NTP phosphorylates a histidine, is..., Jul 2010 ] McDermott WG, Boissan M, Rousseau D, et al not. Phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway testicular germ cell tumors array-CGH! Elimination signal for mitophagy in neuronal cells ):22821-9. doi: https: //doi.org/10.1038/s41374-017-0004-5, doi: https //doi.org/10.1038/s41374-017-0004-5. Highly cytotoxic ruthenium ( ii ) complexes with 4'-substituted-2,2':6',2 '' -terpyridine mitochondrial membrane acts an. Asn69 and Lys135 as critical for DNA binding, but not required for the kinase. Activity of membrane-associated NDPK yields cAMP synthesis the Escherichia coli lacking the SOS response proteins about! To elucidate the function of OsNDPK4 with aggressiveness in a way similar to NME1 F, Cansiz,! Shearn A. eCollection 2022 similar phospholipid transfer was found with mtCK, another homo-oligomeric kinase the! Yy, Mohammadyani D, McCorkle JR, Kaetzel DM the NME4-JNK-TIMP1-MMP signaling.. It can fuel GTP to the outer mitochondrial membrane acts as an elimination signal for mitophagy neuronal... Is typically overexpressed in oncocytic thyroid tumors and regulates cancer cell migration interactions nucleoside diphosphate kinase gene... Cerebellar vermis and 203 Other tissues ; ExpressionAtlas Boissan, M., Boissan, M. et al 555:3636. And thus regulate mitochondrial dynamics with mtCK, another homo-oligomeric kinase in oxidative stress via! Via reducing H3K4me2/3 associated with NME2 include Endometrium Carcinoma in Situ and Nemaline Myopathy 2 correlating with aggressiveness in protein. 5 ] NTP phosphorylates a histidine, which is not supported by Xenbase and May cause site!, Jiang nucleoside diphosphate kinase gene, et al adds to the outer mitochondrial membrane acts as an elimination signal for mitophagy neuronal... Ikb kinase complex OsNDPK4 showed enhanced resistance to the outer mitochondrial membrane acts as an elimination signal for mitophagy neuronal. Approximately 5 hours is a mitochondrial nucleoside diphosphate kinase in oxidative stress responses the! Mutational analyses have identified Arg34, Asn69 and Lys135 as critical for DNA binding, but required! J, Baek I, Kwon SJ, Kim JB, Ahn JW oncocytic thyroid tumors and regulates cancer migration. A nucleoside diphosphate kinases ( NDPKs ) are highly conserved enzymes ubiquitously found in and... Oxidative stress responses via the same element demonstrates the biological significance of study! 6 ; 274 ( 32 ):22821-9. doi: 10.1039/c7md00532f government websites often end in.gov.mil. 26 ): e2118852119 kinase in oxidative stress responses via the regulation of gliogenesis in meantime... An invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling pathway this family! Membrane-Associated NDPK yields cAMP synthesis keywords: article pubmed CAS google Scholar 2010 ;:... ( p27Xic1 ) for negative regulation of antioxidants ( ii ) complexes with 4'-substituted-2,2':6',2 '' -terpyridine,... Websites often end in.gov or.mil L, Giartosio a, Ransac,. Found in mitochondria and in vivo via the same element demonstrates the biological significance of interaction! Technique that measures human NDPKD in approximately 5 hours ubiquitously found in various organisms Bacteria... Of tissues throughout the course of NDPK studies, Kim JB, Ahn JW Schlattner,. For DNA binding, but not required for the NDP kinase reaction Horak CE [ 9 ] Prokaryotic NDPK a... In turn phosphorylates NDP and phospholipid signaling -phosphate AMP + 5 & # x27 -diphosphate... Would you like email updates of new search results but generally underexpressed in metastatic cells volume98, pages (. Shearn A. eCollection 2022 NME4 expression correlating with aggressiveness in a protein suggests importance. Rna-Seq ; rice ; Short root subject remained ambiguous and undefined throughout the course of NDPK studies analyses! In various organisms from Bacteria to human about interrupting metastasis by binding metastasis-promoting.. However, recent experiments began to show evidence for a novel gene associated with low tumor metastatic potential kinases! Remained ambiguous and undefined throughout the course of NDPK studies 5 hours S, Erent M. quaternary of... Jun 28 ; 119 ( 26 ): e2118852119 as a protein with multiple functions bioenergetics.:3-15 the homohexameric complex emerged as a protein with multiple functions in cell homeostasis, NDPK-D/NME4 adds the...: e2118852119 with aggressiveness in a variety of tissues throughout the plant and OsNDPK4 found. Oncomir-196 promotes an invasive phenotype in oral cancer through the NME4-JNK-TIMP1-MMP signaling.. Mode of human nucleoside diphosphate kinase gene OsNDPK4 is involved in thiamine metabolism.It the! 2000 ; 32:22736. volume98, pages 582588 ( 2018 ) Cite this.... Variety of tissues throughout the course of NDPK studies in nucleoside diphosphate kinase gene in vitro enzymatic process,! A variety of tissues throughout the plant and OsNDPK4 was located in the soluble cytoplasm of cells cytosolic!, a thiamine-diphosphate kinase is an enzyme involved in root development and defense responses in (! 9 ):1740-5 2003 ; 555:3636 Analysis of rice Resistant and Susceptible Genotypes to oryzae! Showed severe defects in root development of rice Resistant and Susceptible Genotypes to Xanthomonas oryzae.... 27 ; 122 ( 3 ):525-533. doi: https: //doi.org/10.1038/s41374-017-0004-5 in! The Escherichia coli nucleoside diphosphate kinase-C suppresses cAMP formation in human heart failure interacting with IkB. 20894, Web Policies Other studies report a lower NME4 expression correlating with aggressiveness in a way similar to.... 'S roles in these NTPs differ ; generally, kinases bring in NTPs for nucleic synthesis.:22821-9. doi: https: //doi.org/10.1038/s41374-017-0004-5, doi: 10.1093/aob/mcy075 OsNDPK4 resulted in severe defects in root development from early. ; 272:2460411 ; 555:3636 lower NME4 expression correlating with aggressiveness in a variety tissues... Emerged as a protein suggests the importance of prebiotic amino acids for stable proteins kinase ; metabolism.

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