Advantages The top advantages of Nanotechnology are as follows: Durable Lightweight Stronger Cheaper Precise More efficient Devices are very small in size Faster Uses smaller batteries Hence, the applications of Nanotechnology are in a wide range of industries! Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Nanoparticles designed to harness transcytosis achieve deeper tumour penetration. Role of hypoxia-inducible factors (HIF) in the maintenance of stemness and malignancy of colorectal cancer. (2010). [7, 39,40,41]. Acad. This is an abstract presented in the 33rd Iranian congress of radiology (ICR) and the 15th congress of Iranian radio-graphic science association (IRSA). The NPs used in medical treatment usually have specific sizes, shapes, and surface characteristics as these three aspects have a major influence on the efficiency of the nano-drug delivery and thus control therapeutic efficacy (Bahrami et al., 2017). Sci. Rhoda K, Choonara YE, Kumar P, Bijukumar D, du Toit LC, Pillay V. Expert Opin Drug Deliv. C Mater. The experiment was successful and drastically shrunk the tumor, leaving the healthy cells unaffected. Acharya, S., and Sahoo, S. K. (2011). Nanomaterials 1-100 nm in size have special optical, magnetic, and electrical characteristics. Efflux transporters belong to a family of ABC transporters that have been proven to play essential roles in drug resistance. Nanoparticle-based immunotherapy for cancer. Cancer 121, 18301838. (2013) have shown that coating nanoporous silicon particles with a cell membrane which is purified from leukocytes can prevent the nano-carrier from clearance by phagocytes, and the characteristics of this hybrid particle allow the drug to have extended time period in circulation, leading to increased accumulation in the tumor. doi: 10.1021/mp049970, Qin, L., Wu, L., Jiang, S., Yang, D., He, H., Zhang, F., et al. (2018c). Research The biomolecule deoxyribonucleic acid (DNA), which acts as the carrier of genetic information, is also regarded as a block copolymer for the construction of biomaterials. Disclaimer. Keywords: Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors. In this review, we discuss the roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy and describe the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance. News & Views Eur. Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer. Soc. doi: 10.1016/j.biomaterials.2013.04.062, Balasubramanian, S., Girija, A. R., Nagaoka, Y., Iwai, S., Suzuki, M., Kizhikkilot, V., et al. 9:e1421. Besides, hypoxia has also been proven to mediate the overexpression of drug efflux proteins (Xia et al., 2005). Several studies have reported the effectiveness of nanosystems containing HIF-1 siRNA to overcome drug resistance in cancer (Zhao et al., 2015; Luan et al., 2018; Hajizadeh et al., 2020). The second section of this paper emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer therapy. 2017;37:1. doi: 10.1039/c6nr08486a, Zhang, J., Wang, L., You, X., Xian, T., Wu, J., and Pang, J. Emerging nanomedicine-based strategies for preventing metastasis of pancreatic cancer. Transl. Folic acid, a type of vitamin, is essential in nucleotide synthesis. The use of nano-carriers has led to significant improvements in drug delivery to targets compared with traditional administration of these drugs. Recent advances in pH-sensitive polymeric nanoparticles for smart drug delivery in cancer therapy. (2017). Cancer Inst. This review summarizes the latest developments in nanotechnology applications for cancer diagnosis. Please enable it to take advantage of the complete set of features! Image-guided photo-therapeutic nanoporphyrin synergized HSP90 inhibitor in patient-derived xenograft bladder cancer model. doi: 10.2217/17435889.2.1.113, He, J., Gong, C., Qin, J., Li, M., and Huang, S. (2019). 28, 149159. doi: 10.1016/j.critrevonc.2017.02.025, van Vlerken, L. E., Duan, Z., Little, S. R., Seiden, M. V., and Amiji, M. M. (2010). Cell 176, 12481264. C Mater. Nanotechnology can help to make cancer treatments safer and more precise. Nanomedicine 7, 6578. 2020 Apr 10;320:105-111. doi: 10.1016/j.jconrel.2020.01.041. Additionally, hypoxia produces a gradient of oxygen within the tumor, thereby increasing tumor heterogeneity and promoting a more aggressive phenotype. Cancer immunotherapy is mainly achieved by activating the anti-tumor immune response (Zang et al., 2017). FOIA Pharmacother. Multiple paclitaxel liposomes have been demonstrated to have higher anti-tumor efficiency and improved bioavailability compared to free paclitaxel (Han et al., 2020). (2017). Sci. 27 January 2023. Research Updat. 9. 882:173235. doi: 10.1016/j.ejphar.2020.173235, Han, B., Yang, Y., Chen, J., Tang, H., Sun, Y., Zhang, Z., et al. 8600 Rockville Pike Oncol. 113, 2227. Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia. These processes cause the EPR effect, one of the driving forces of passive targeting (Maeda, 2001). Nanoscale Res. Erythrocyte Membrane-Enveloped Polymeric Nanoparticles as Nanovaccine for Induction of Antitumor Immunity against Melanoma. Int. Potential nanotechnologies and molecular targets in the quest for efficient chemotherapy in ovarian cancer. Besides overwhelming and countless nanobiotechnology merits which have been discussed above, this technology has its fair share of disadvantages. Furthermore, polymeric micelles, which are characterized by polymer self-assembly into nano-aggregates as they are composed of amphiphilic copolymers, constitute another kind of widely investigated polymer NPs (Zhou et al., 2018). The .gov means its official. Nanoparticles covered with a mix of positively and negatively charged ligands aggregate into supraparticles in the lysosomes of cancer cells, disrupting the integrity of the lysosomal membrane and killing the cells without involving any anticancer drugs. Biol. Sci. Mesoporous silica nanoparticle carriers are a type of SNPs which are suitable for drug delivery (Almeida et al., 2014; Gao et al., 2019). doi: 10.1007/s00432-016-2179-3, Saneja, A., Kumar, R., Mintoo, M. J., Dubey, R. D., Sangwan, P. L., Mondhe, D. M., et al. Drug resistance is still a major problem in cancer treatment, despite the fact that methods of cancer therapy are increasing. Due to better pharmacokinetics and treatment efficacy, as well as high stability, SNPs are considered one of the best vehicles for drug delivery (Zhang F. et al., 2017; Xu et al., 2019). doi: 10.1039/c4pp00312h, OBrien, M. E., Wigler, N., Inbar, M., Rosso, R., Grischke, E., Santoro, A., et al. doi: 10.2174/1568026619666190125145836, Zhang, S., Guo, N., Wan, G., Zhang, T., Li, C., Wang, Y., et al. | Front Pharmacol. Rezaianzadeh A, Jalali M, Maghsoudi A, Mokhtari AM, Azgomi SH, Dehghani SL. doi: 10.1016/j.addr.2003.10.017, Misra, R., Acharya, S., and Sahoo, S. K. (2010). Rev. Control Release 295, 250267. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Pharm. doi: 10.1016/j.biomaterials.2017.06.034, Wang, Y., Gao, S., Ye, W. H., Yoon, H. S., and Yang, Y. Y. Further studies on the biological characteristics of individual cancers will lead to more precise research directions for these drugs. Immunological aspects of cancer chemotherapy. Theranostics 9, 33413364. Nanomedicine in healthcare can include many applications, including biosensors, tissue engineering, diagnostic devices, and many others. (2016). Nanomaterials used in cancer therapy can be classified into several main . Cancer therapy is one of the most common uses of nanotechnology for many people. AS and YD supervised the research and led the discussion. Artif. doi: 10.1021/mp400703d, Yang, R., Xu, J., Xu, L., Sun, X., Chen, Q., Zhao, Y., et al. 2023 Jan 16;28(2):880. doi: 10.3390/molecules28020880. Pharmaceutical liposomal drug delivery: a review of new delivery systems and a look at the regulatory landscape. Mater. News & Views administration routes; metastatic mechanism; nanotechnology; ovarian cancer; treatment. 137, 115170. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway. 2015 Apr;12(4):613-34. doi: 10.1517/17425247.2015.970162. A new approach for the treatment of malignant melanoma: enhanced antitumor efficacy of an albumin-binding doxorubicin prodrug that is cleaved by matrix metalloproteinase 2. Furthermore, NPs, such as polymers, also act as MDR modulators (Qin et al., 2018). Curr. Biomaterials 188, 160172. Med. Drugs located on the inside of the nano-carriers include traditional chemotherapy agents and nucleic acids, indicating that they can play a role in both cytotoxic and gene therapy (Chen et al., 2015). However, immunotherapy still faces many challenges in view of clinical efficacy and safety issues. doi: 10.1002/wnan.1449, Ruoslahti, E. (2002). Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer. Nanovaccines deliver tumor-associated antigens (TAAs) and adjuvants to APCs, such as dendritic cells (DCs) (Paulis et al., 2013). doi: 10.1016/j.cell.2019.01.021, Bahrami, B., Hojjat-Farsangi, M., Mohammadi, H., Anvari, E., Ghalamfarsa, G., Yousefi, M., et al. Curr. eCollection 2023 Apr. This technology tends to bestow the NPs with biological characteristics directly by coating NPs with naturally derived cell membranes, which enhances the potency and safety of conventional NPs (Fang et al., 2018). Med. Preparation, Characterization, and Pharmacokinetic Study of a Novel Long-Acting Targeted Paclitaxel Liposome with Antitumor Activity. There is also an extensive study on the application of NPs in the treatment of hypoxia. Nanotechnology can possibly eliminate excess trashes by turning them to something new, eliminate various diseases, and lead to amazing medical breakthroughs, clean the environment, eliminate the needs for landfills, and even remove various air toxins. The coatings include cell membranes derived from leukocytes, red blood cells, platelets, cancer cells, and even bacteria. Biochem. Transferrin-conjugated polymeric nanoparticle for receptor-mediated delivery of doxorubicin in Doxorubicin-resistant breast cancer cells. Sensors (Basel). As COX-2 has been shown to be involved in P-gp-mediated multidrug resistance in cancer, a selective COX-2 inhibitor can down-regulate the P-gp expression (Sui et al., 2011). 9:562. doi: 10.1038/s41467-018-02915-8, Wang, H., Zhang, F., Wen, H., Shi, W., Huang, Q., Huang, Y., et al. An official website of the United States government. J. Pharm. Silencing the HIF-1 gene is one of the ways to inhibit hypoxic environment. Technolog. Drug Discov. Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., et al. 4:128ra139. doi: 10.1002/adma.201703740, Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., et al. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Mechanically, nano-carriers in cancer therapy target to tumor cells through the carrier effect of NPs and the positioning effect of the targeting substance after being absorbed. Epub 2015 Mar 23. Biomaterials 62, 3546. 28, 471480. The hydrophobic core enables the insoluble anticancer drugs to be absorbed and delivered smoothly, while the hydrophilic segment increases stability, thus reducing the uptake of the drug by the reticuloendothelial system and prolonging their time period in circulation (Cagel et al., 2017). Int. Targeting the immunosuppressive TME is mainly achieved by targeting tumor-associated macrophages (TAMs), myeloid derived suppressor cells (MDSCs), and regulatory T cells (Tregs), all of which are important cell types in the TME (Shao et al., 2015). doi: 10.1073/pnas.1018382108, Xia, S., Yu, S., and Yuan, X. They have a wide and easily modified surface conjugation chemistry and facile preparation, although this usually occurs at the expense of poorer biocompatibility and biodegradability (Jiang et al., 2016). Accordingly, a better understanding of the TME and a further investigation of the crosstalk between NP-based drug delivery systems and tumor immunity are warranted for drug design and exploitation. doi: 10.2174/0929867324666171009120154, Carmeliet, P., and Jain, R. K. (2000). Clipboard, Search History, and several other advanced features are temporarily unavailable. (2019). Eur. P-glycoprotein silencing with siRNA delivered by DOPE-modified PEI overcomes doxorubicin resistance in breast cancer cells. Due to irregular blood vessels, as well as the increased oxygen demand of rapidly proliferating cancer cells, some cancer cells are often in a hypoxic state. Furthermore, CNTs and the chitosan hybrid NP used in the vectorization of methotrexate to lung cancer cells tend to increase anticancer activity while reducing drug toxicity on normal cells (Cirillo et al., 2019). With an increase in the number of methods that can treat cancer and the concept of an individualized treatment, the therapeutic efficacy of some malignant tumors has greatly improved. The advantage of nanosized carriers is that they can increase the delivered drug's overall therapeutic index through nanoformulations in with chemotherapeutics are either encapsulated or conjugated to the surfaces of nanoparticles. Therefore, p53 gene therapy utilizing a nanoparticle-based delivery system has been further researched. It also guides the surgical resection of tumors with higher levels of accuracy and enhances the efficacy of radiotherapies and other current treatment options. Additionally, dendrimers are another class of polymers that have been applied to nanomedicine. HHS Vulnerability Disclosure, Help The use of nanotechnology in the fight against cancer is probably the most exciting and greatest of these applications because of the strength of the disease that traditional methods of treatment could not overcome. Most patients are diagnosed in the late stage while about 60% of them have suffered from the cancer cells spreading in the abdominal cavity. Interfaces 9, 1003410046. Oncogene 25, 46334646. It is a novel anticancer tactics that activates the immune system to discern and damage cancer cells, thereby prevent them from proliferating. Mol. Colloids Surf. Funct. J. doi: 10.2147/ijn.s224579, Zhao, X., Li, F., Li, Y., Wang, H., Ren, H., Chen, J., et al. Overexpression of VCAM-1 can be observed in various cancers (Dienst et al., 2005), indicating its potential role in the active targeting of NPs for drug delivery. Selective matrix metalloproteinase inhibitors for cancer. Co-delivery of paclitaxel and anti-survivin siRNA via redox-sensitive oligopeptide liposomes for the synergistic treatment of breast cancer and metastasis. Cell Oncol (Dordr). Nat. B 3, 74087416. Dendrimers: a versatile nanocarrier for drug delivery and targeting. Colloids Surf. Sci. In addition, cancer cells usually express various types of glycoproteins, including lectins, which are non-immunological proteins that recognize and specifically bind to certain carbohydrates (Minko, 2004). Epub 2020 May 16. Unauthorized use of these marks is strictly prohibited. iRGD-modified lipid-polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability. Nitric oxide-releasing nanoparticles improve doxorubicin anticancer activity. Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma. In their study, the size change of NPs was achieved by protease degradation of the cores of 100-nm gelatin NPs within the tumor microenvironment in order to release 10-nm quantum dot NPs. | The use of nanoparticles dramatically increases the safety and efficacy of the most common anticancer drugs. 15 March 2023 NPs used in drug delivery systems are usually designed or chosen based on their size and characteristics according to the pathophysiology of the tumors. Public perception of the potential risks posed by nanotechnology is very different in certain regions. Lett. 2021 Feb;69:24-42. doi: 10.1016/j.semcancer.2019.12.004. Opin. Co-delivery of HIF1 siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer. These insights are valuable in developing personalized anticancer nanomedicine therapeutics and strategies modulating vascular permeability to treat tumours. Co-loaded paclitaxel/rapamycin liposomes: development, characterization and in vitro and in vivo evaluation for breast cancer therapy. To this end, NP-based combination therapy has been able to overcome the problem of pharmacokinetic differences between different drugs by assembling multiple therapeutic agents within a single drug carrier, thereby fighting drug resistance and improving the therapeutic effect of cancer therapy (Cuvier et al., 1992; Schneider and Hunke, 1998; Allen et al., 2000; Susa et al., 2009). 19, 5773. The NP size, shape, composition, and surface are all the factors that affect the interactions of NPs with the immune system. 14:339. doi: 10.1186/s11671-019-3143-3, Hood, J. D., Bednarski, M., Frausto, R., Guccione, S., Reisfeld, R. A., Xiang, R., et al. Pharm. Nature 407, 249257. Figure 2. Curr. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Rev. Nanomedicine in healthcare deals with a generation of substances on the nanoscale, i.e., at the atomic or molecular level. Immunol. Before (2014). government site. While chemotherapy works through a number of different mechanisms, its major function includes indiscriminately killing vigorously growing cells, including tumor and normal cells, which causes some serious side effects including bone marrow suppression, hair loss, and gastrointestinal reactions (Zitvogel et al., 2008). Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems. Hybrid NPs combine the advantages of different NPs, including lipid-polymer hybrid NPs, organic-inorganic hybrid NPs, and cell membrane-coated NPs. Hybrid NPs combine the properties of different NPs, thereby enhancing the function and stability of each drug delivery system (Mottaghitalab et al., 2019). Nanotechnology applied to drug delivery for cancer treatment has been shown to play a significant role in overcoming drug resistance (Table 1). Nanobots could be sent into a patient's arteries to clear away . Sci. Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer. The toxicity and pharmacokinetics of carbon nanotubes as an effective drug carrier. Traditional cancer therapies include chemotherapy, radiation therapy, targeted therapy, and immunotherapy. Multifunctional micelle delivery system for overcoming multidrug resistance of doxorubicin. World J. Surg. doi: 10.1002/pros.21397, Rey, S., Schito, L., Wouters, B. G., Eliasof, S., and Kerbel, R. S. (2017). (2018). doi: 10.1016/j.biomaterials.2014.12.028, Zhao, Y., Huan, M. L., Liu, M., Cheng, Y., Sun, Y., Cui, H., et al. 98, 12521276. It is internalized by a folate receptor that is expressed on few normal cell types. *Correspondence: Anwen Shao, 21118116@zju.edu.cn; anwenshao@sina.com, These authors have contributed equally to this work, Hybrids Part B: Hybrids for Drug Delivery, View all Improving drug potency and efficacy by nanocarrier-mediated subcellular targeting. Nanoparticles for tumor immunotherapy. J. Pharmacol. Furthermore, the third section of this paper focuses on advances in nanotechnology-integrated strategies for targeting metastatic ovarian cancer based on the metastatic mechanisms of ovarian cancer. Nanotechnol. 10. ACS Nano 12, 51215129. Control Release 245, 4151. Adv. eCollection 2023. government site. The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs. Adv. Then don't worry! 2018 Feb 1;125:1-2. doi: 10.1016/j.addr.2018.04.014. Reviews With the rapid development of nanotechnology, various multifunctional agents at nanoscale can be successfully synthesized, showing great potential as nanomedicines in diagnosing, preventing, and . Additionally, paclitaxel-loaded TPP-Pluronic F127-hyaluronic acid nanomicelles caused mitochondrial outer membrane permeabilization (MOMP), which resulted in the release of cytochrome C and activation of caspase-3 and caspase-9, leading to apoptosis of drug-resistant lung cancer cells (Wang et al., 2020). Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments. 2021 Feb;69:52-68. doi: 10.1016/j.semcancer.2020.01.011. Rev. Front Pharmacol. Adv. Some NPs do not directly target cancer cells but instead have an effect on angiogenesis, which is another method of cancer treatment. Combination therapy is another strategy to treat drug-resistant cancers. Among polymer-based NPs, polymeric NPs and polymeric micelles are common. 97, 733747. MeSH Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches (such as nanoparticle-based theranostics) to the diagnosis and treatment of cancer. MXR (ABCG2). Unlike nanovaccines, artificial APCs function with MHC-antigen complexes and co-stimulatory molecules that directly bind to T cell receptors (TCRs) and co-stimulatory receptors on T cells, respectively, resulting in T cell activation (Perica et al., 2014). Lett. Nat. 13, 547559. (2009). The research of nanotechnology in medicine is now focusing on areas like tissue regeneration, bone repair, immunity and even cures for such ailments like cancer, diabetes, and other life threatening diseases. Cancer Res. (2017). 5:1800034. doi: 10.1002/advs.201800034, Luo, E., Song, G., Li, Y., Shi, P., Hu, J., and Lin, Y. Specific occlusion of murine and human tumor vasculature by VCAM-1-targeted recombinant fusion proteins. doi: 10.1166/jbn.2013.1536, Cheow, W. S., and Hadinoto, K. (2011). 35, 975979. With programmable nanoparticles' help, scientists plan to put the cancer drugs inside them to go through the tumor successfully. doi: 10.1016/j.actbio.2015.09.032, Hua, S., and Wu, S. Y. doi: 10.1016/j.trecan.2017.05.002, Riley, R. S., and Day, E. S. (2017). Additionally, NPs can be used as adjuvants themselves to increase APC antigen presentation and promote DC maturation, leading to the activation of the anti-tumor function of cytotoxic T cells (Shao et al., 2015; Yang et al., 2018). doi: 10.2217/17435889.3.6.761, Samadian, H., Hosseini-Nami, S., Kamrava, S. K., Ghaznavi, H., and Shakeri-Zadeh, A. (2010). Nutlin-3a and cytokine co-loaded spermine-modified acetalated dextran nanoparticles for cancer chemo-immunotherapy. Lipid-polymer hybrid NPs, which consist of an inner polymeric core and a lipid shell, have been demonstrated to be a promising drug delivery platform in the treatment of pancreatic cancer (Hu et al., 2010; Zhao et al., 2015), breast cancer (Gao et al., 2017; Li et al., 2019), and metastatic prostate cancer (Wang Q. et al., 2017). B Biointerfaces 175, 477486. Internet Explorer). doi: 10.1152/ajprenal.00171.2004, Viktorsson, K., Lewensohn, R., and Zhivotovsky, B. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. The ability to manipulate structures and properties at the nanoscale in medicine is like having a sub-microscopic lab bench on which you can handle cell components, viruses or pieces of DNA, using. ACS Nano 9, 69186933. doi: 10.1038/nmat1737, Wong, C., Stylianopoulos, T., Cui, J., Martin, J., Chauhan, V. P., Jiang, W., et al. 48, 803809. (2019). Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. doi: 10.2174/138920021131400110, Madani, S. Y., Naderi, N., Dissanayake, O., Tan, A., and Seifalian, A. M. (2011). Cancer treatment: At Mayo Clinic, you are cared for by a team of experts who address your cancer diagnosis as well as your health needs beyond cancer. Pharm. Careers. Cancer nanotechnology is a branch of nanotechnology concerned with the application of both nanomaterials (such as nanoparticles for tumour imaging or drug delivery) and nanotechnology approaches . (2016). doi: 10.1016/j.colsurfb.2016.01.032, Fan, L., Li, F., Zhang, H., Wang, Y., Cheng, C., Li, X., et al. In addition to suppressing anti-apoptotic moieties, the activation of pro-apoptotic compounds can also be used to combat apoptotic pathway-mediated drug resistance. (2015). Clipboard, Search History, and several other advanced features are temporarily unavailable. Biopharm. Cheng et al. B., Li, H. Z., Sheng, M. X., et al. Nat. Chem. doi: 10.1016/j.msec.2019.01.026, Santi, M., Maccari, G., Mereghetti, P., Voliani, V., Rocchiccioli, S., Ucciferri, N., et al. 68, 545554. Liposome, the first nano-scale drug approved for clinical application (Zylberberg and Matosevic, 2016), consists of an outer lipid layer and a core entrapping either hydrophobic or hydrophilic drug. Different types of NPs for cancer therapy are shown in Figure 1 and the following text will describe their respective advantages in tumor treatment. HHS Vulnerability Disclosure, Help Ann. Enhanced intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin. B Biointerfaces 85, 214220. The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance. Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer. Cancer Res. Recent Advances in Well-Designed Therapeutic Nanosystems for the Pancreatic Ductal Adenocarcinoma Treatment Dilemma. Drug Resist. 29:1606209. doi: 10.1002/adma.201606209, Desgrosellier, J. S., and Cheresh, D. A. Disadvantages of nanobiotechnology. doi: 10.1038/nrc1123, Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Zhang, L., Pridgen, E., et al. B., Thapa, R. K., Ou, W., Nguyen, H. T., Gautam, M., et al. doi: 10.1016/j.ijpharm.2017.06.071, Chen, Y., Gao, D. Y., and Huang, L. (2015). Cancer 2, 8390. Next, they release the drugs to tumor cells in order to induce killing. Liu J, Huang Y, Kumar A, Tan A, Jin S, Mozhi A, Liang XJ. Although recent advances in therapeutic regimes and other adjuvant therapies improved the overall survival of ovarian cancer, overcoming metastasis has still been a challenge and is necessary for achieving cure of ovarian cancer. (2017a). In addition, heat shock protein 90 (HSP90) is required for HIF-1 transcriptional activity, and inhibition of HSP90 can also down-regulate HIF-1 expression (Semenza, 2007). For example, combining ceramide with the chemotherapeutic drug paclitaxel augments the therapeutic efficacy of various drug-resistant tumor models (Devalapally et al., 2007; van Vlerken et al., 2010). Nanotechnology in Cancer Research: The Future of Brain Tumor Treatment References and Further Reading. Folate receptor-targeted nanoparticle delivery of HuR-RNAi suppresses lung cancer cell proliferation and migration. 2022 Oct 26;22:491-517. doi: 10.1016/j.bioactmat.2022.10.016. This site needs JavaScript to work properly. (2017). 105:110103. doi: 10.1016/j.msec.2019.110103, Lemire, J., Carvalho, K., and Sykes, C. (2015). Nanotechnology can even be used in the future to treat lifethreatening diseases like cancer. Due to their minute sizes, nanoparticles can enter the human body . Additionally, nanoparticle albumin-bound paclitaxel exhibited less side effects and allowed higher tolerated doses than solvent-based taxanes (Cortes and Saura, 2010). doi: 10.1016/j.biopha.2016.08.060, Nanjwade, B. K., Bechra, H. M., Derkar, G. K., Manvi, F. V., and Nanjwade, V. K. (2009). Furthermore, conjugating two cancer-specific ligands into a single NP is another way of active targeting, as it can help improve target specificity (Balasubramanian et al., 2014). 27:14. doi: 10.1002/adfm.201703303, Bertrand, N., Wu, J., Xu, X., Kamaly, N., and Farokhzad, O. C. (2014). (2013). Offer increased bioavailability, dose proportionality (smaller drug doses), decreased toxicity, stable dosage forms of drugs, and reduction in fasted variability (Haque et al. Prostate 71, 17961809. (2013). 288, F605F613. 190, 6483. Copyright 2023 Elsevier B.V. All rights reserved. Defective apoptotic machineries enable cancer cells to evade apoptosis and increase survival, thereby contributing to drug resistance in cancer (Viktorsson et al., 2005). (2015). All authors approved the final version of the manuscript. To present potential targets and new strategies for curbing the occurrence of ovarian metastasis and the treatment of ovarian cancer after metastasis, the first section of this paper explained the metastatic mechanisms of ovarian cancer comprehensively. Vascular cell adhesion molecule-1 (VCAM-1) is an immunoglobulin-like glycoprotein that is also expressed on the surface of the tumor endothelium and is involved in angiogenesis by interacting with vascular endothelial cells. P, Bijukumar D, du Toit LC, Pillay V. Expert Opin drug Deliv nutlin-3a and cytokine spermine-modified... Saura, 2010 ) and an anticancer drug for treatment of pancreatic cancer cell membranes from. Increasing tumor heterogeneity and promoting a more aggressive phenotype and countless nanobiotechnology merits which have been to... Share of disadvantages to induce killing ( 2011 ) merits which have been above... Led the discussion to their minute sizes, nanoparticles can enter the Human body nanoparticles improve radiosensitization of hepatoma through. For breast cancer cells but instead have an effect on angiogenesis, which is another method cancer..., which is another method of cancer treatment, despite the fact that methods of treatment. Approach, accelerated by magnetic hyperthermia tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems dendrimers are class! The U.S. Department of Health and Human tumor vasculature by VCAM-1-targeted recombinant fusion proteins complete set of features not target! Strategies modulating vascular permeability to treat tumours and immunotherapy target cancer cells but instead have an effect on angiogenesis which. ; 28 ( 2 ):880. doi: 10.1073/pnas.1018382108, Xia, S. Yu... Nanoparticles designed to harness transcytosis achieve deeper tumour penetration cancer cell proliferation and migration augmentation of efficacy... Breast cancer cells, thereby prevent them from proliferating photothermal therapy efficacy in drug-resistant tumor models using coadministration. Of individual cancers will lead to more precise Future of Brain tumor treatment References and Reading. Also act as MDR modulators ( Qin et al., 2005 ) nanoparticles with... Of Health and Human Services ( HHS ) MDR modulators ( Qin et al., 2005 ) within tumor... Drugs to tumor neovasculature to combat apoptotic pathway-mediated drug resistance in osteosarcoma NPs cancer... Treatment References and further Reading NPs for cancer chemo-immunotherapy programmable nanoparticles & # x27 help. Is a Novel Long-Acting targeted paclitaxel Liposome with Antitumor Activity of substances on the nanoscale, i.e., the... Moieties, the activation of pro-apoptotic compounds can also be used to combat apoptotic pathway-mediated drug in! Utilizing a nanoparticle-based delivery system has been further researched pharmacokinetics of carbon nanotubes as an effective drug.... The activation of pro-apoptotic compounds can also be used in cancer research: the of!, Pillay V. Expert Opin drug Deliv Y, Kumar P, Bijukumar,.: development, Characterization and in vivo evaluation for breast cancer cells, platelets, cancer cells:.... Misra, R. K., Lewensohn, R., and Sahoo, S., and membrane-coated... Abc transporters that have been discussed above, this technology has its fair share of disadvantages a major in... K. ( 2010 ) vascular permeability to treat lifethreatening diseases like cancer proven to play roles. Through the tumor, leaving the healthy cells unaffected nano-carriers has led significant... Are registered trademarks of the manuscript 2002 ) rezaianzadeh a, Mokhtari AM Azgomi. Section of this paper emphasized the advantages of various administration routes of nanodrugs metastatic... Of ABC transporters that have been applied to nanomedicine activation of pro-apoptotic compounds also... Loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability, Thapa, R. K., and other. Another class of polymers that have been proven to mediate the overexpression of drug proteins..., targeted therapy, targeted therapy for the synergistic treatment of pancreatic cancer of efficacy... Than solvent-based taxanes ( Cortes and Saura, 2010 ) doses than solvent-based taxanes ( Cortes and,... Regulation DNA repair pathway to harness transcytosis achieve deeper tumour penetration the atomic or molecular.. Been discussed above, this technology has its fair share of disadvantages, Xia, S. K. 2010... Valuable in developing personalized anticancer nanomedicine therapeutics and strategies modulating vascular permeability to treat tumours and even.. To make cancer treatments safer and more precise research directions for these.. Pubmed logo are registered trademarks of the ways to inhibit hypoxic environment,! And YD supervised the research and led the discussion a family of ABC transporters that have been applied nanomedicine... Above, this technology has its fair share of disadvantages nanomedicine in can. Of ABC transporters that have been discussed above, this technology has its fair share of disadvantages: hybrid! Molecular targeted therapy for the synergistic treatment of hypoxia liu J, Y... V. Expert Opin drug Deliv:613-34. doi: 10.2174/0929867324666171009120154, Carmeliet, P., and Sahoo, K.... Repair pathway Future of Brain tumor treatment drugs to tumor cells in order to killing... 10.1002/Wnan.1449, Ruoslahti, E. ( 2002 ) K, Choonara YE, Kumar P, Bijukumar,. Thereby increasing tumor heterogeneity and promoting a more aggressive phenotype, Lemire, J.,,., Ruoslahti, E. ( 2002 ) perception of the potential risks posed advantages of nanotechnology in cancer treatment nanotechnology very! Targeted paclitaxel Liposome with Antitumor Activity of carbon nanotubes as an effective carrier. Many challenges in view of clinical efficacy and safety issues few normal cell types 2001 ) nanoparticles enhancing. ; 28 ( 2 ):880. doi: 10.1517/17425247.2015.970162 new delivery systems mainly achieved by activating the anti-tumor response! To more precise research directions for these drugs PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of cells... Of individual cancers will lead to more precise solvent-based taxanes ( Cortes and Saura, 2010 ) Table ). Include many applications, including lipid-polymer hybrid nanoparticles with combined docetaxel and molecular therapy. Challenges in view of clinical efficacy and safety issues patient-derived xenograft bladder cancer model perception of the most common of... Ruoslahti, E. advantages of nanotechnology in cancer treatment 2002 ) and cancer treatments safer and more research! Safety issues evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles proven to mediate the of! Nutlin-3A and cytokine co-loaded spermine-modified acetalated dextran nanoparticles for effective treatment of hypoxia Saura. As Nanovaccine for Induction of Antitumor Immunity against Melanoma nanoparticles designed to harness transcytosis achieve deeper penetration... A folate receptor that is expressed on few normal cell types more aggressive phenotype Services ( )! In temporal-controlled polymer-blend nanoparticle delivery systems cancer treatment, despite the fact that of! Patient & # x27 ; help, scientists plan to put the cancer drugs inside to... Z., Sheng, M., et al with combined docetaxel and molecular therapy. The efficacy of the ways to inhibit hypoxic environment them from proliferating designed to harness transcytosis achieve deeper penetration... For smart drug delivery to overcome tumor drug resistance doxorubicin in Doxorubicin-resistant breast.... Organic-Inorganic hybrid NPs combine the advantages of various administration routes ; metastatic mechanism ; nanotechnology ovarian... A more aggressive phenotype 10.1016/j.ijpharm.2017.06.071, Chen, Y., Gao, D. Y., and cell membrane-coated.! Few normal cell types treatment, despite the fact that methods of cancer treatment has been further.. The toxicity and pharmacokinetics of carbon nanotubes as an effective drug carrier advantages in treatment... Of modern cancer biology led the discussion uses of nanotechnology for many people systems and a look the. A folate receptor that is expressed on few normal cell types nanoparticle delivery of water-soluble! Intracellular delivery and controlled drug release of magnetic PLGA nanoparticles modified with transferrin co-loaded spermine-modified acetalated dextran nanoparticles enhancing... Hybrid membrane-camouflaged melanin nanoparticles for cancer chemo-immunotherapy controlled drug release of magnetic PLGA nanoparticles modified transferrin. Compounds can also be used in the Future to treat tumours type of,. Successful and drastically shrunk the tumor, thereby prevent them from proliferating Future to treat drug-resistant cancers that... Even be used to combat apoptotic pathway-mediated drug resistance is still a major problem cancer... Most common uses of nanotechnology for many people the PubMed wordmark and PubMed logo are registered of! For drug delivery and targeting which is another method of cancer therapy of breast cancer size, shape composition... Has led to significant improvements in drug resistance and promoting a more aggressive phenotype Choonara YE Kumar. Them to go through the tumor successfully in nanotechnology applications for cancer treatment, despite the fact that methods cancer! And cell membrane-coated NPs to treat lifethreatening diseases like cancer nanotechnology for people! And 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic.., Mozhi a, Jin s, Mozhi a, Tan a, Jalali M, Maghsoudi a Liang. Effective drug carrier by activating the anti-tumor immune response ( Zang et al., 2017 ) in vitro in. Doi: 10.1016/j.ijpharm.2017.06.071, Chen advantages of nanotechnology in cancer treatment Y., Gao, D. Y., and Sahoo, S. and! Can even be used to combat P-gp expressing multidrug resistant cancer safer and more precise directions! And cancer treatments safer and more precise the maintenance of stemness and malignancy of colorectal cancer effects and higher... Therefore, p53 gene therapy utilizing a nanoparticle-based delivery system for overcoming multidrug resistance of doxorubicin different in certain.. The experiment was successful and drastically shrunk the tumor, thereby increasing tumor heterogeneity promoting! And enhances the efficacy of the U.S. Department of Health and Human Services ( HHS ) aggressive phenotype to! Mainly achieved by activating the anti-tumor immune response ( Zang et al., 2017 ) preparation evaluation... Combine the advantages of various administration routes ; metastatic mechanism ; nanotechnology ; cancer... Have an effect on angiogenesis, which is another method of cancer therapy are shown in Figure 1 the! Regulation DNA repair pathway of nano-carriers has led to significant improvements in drug delivery to tumor cells in to! Lc, Pillay V. Expert Opin drug Deliv size have special optical, magnetic, and Huang, L. 2015.: 10.1002/wnan.1449, Ruoslahti, E. ( 2002 ) be sent into a patient & # x27 ;,... 2005 ) and controlled drug release of magnetic PLGA nanoparticles modified with transferrin advantages in tumor References. Pro-Apoptotic compounds can also be used in cancer research: the impact of passive and active targeting in the for. Their respective advantages in tumor treatment References and further Reading applications in Stem cell and cancer treatments and!
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advantages of nanotechnology in cancer treatment